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Stem cell research guide

GIOSTAR International's Published Research: What Studies Are Measuring

The nine papers PubMed lists under GIOSTAR's founder and its institute, what each reports, and the independent sources that frame them. Education only.
Portrait of Dr. Anand Srivastava, founder of GIOSTAR
In this article

GIOSTAR's founder, Dr. Anand Srivastava, is listed on PubMed as an author of nine peer-reviewed papers with an affiliation at the Global Institute of Stem Cell Therapy and Research, the institute behind GIOSTAR's research ([1] through [9]). This count uses the affiliation on each author line. The papers are reviews and small reports ([1] through [9]). They are not clinical trials ([1] through [9]), and nothing here describes what a GIOSTAR treatment will do for a reader. Full details of the founder are on the founder page.

The field's shared definitions

Researchers in this area use the term mesenchymal stem cells, which a 2006 consensus statement defined by three laboratory criteria: plastic adherence in culture, a set of surface markers, and the ability to form bone, cartilage and fat cells [10]. A 2017 article argued the name should change, because these cells appear to act mainly through the signals they release [11]. The papers below use the term in that sense.

The nine papers

Reviews. Each of these is a narrative review ([2], [3], [5], [6], [7], [8], [9]), which summarizes published work without a formal pooled analysis.

  • 2019, overview of stem cells in tissue regeneration. Covers the types of stem cells and their use in regenerative medicine [2].
  • 2020, stem cell interventions for advanced liver disease. Reviews the clinical studies and argues that controlled trials with long-term follow-up are still needed [3].
  • 2020, stem cell therapy for vitiligo. Reviews the proposed immune and oxidative mechanisms and the reported results of cell-derived treatments [5].
  • 2020, stem cell therapy for inflammatory bowel disease. Reviews the limits of current drugs and the stem cell approaches under study [6].
  • 2021, stem cell therapy in COVID-19. Reviews the immune-modulating rationale for cell therapy in COVID-19 pneumonia [7].
  • 2024, stem cell therapy and diabetes. Reviews the inflammation and cell damage behind diabetes and the stem cell approaches proposed for them [8].
  • 2024, stem cell therapy for osteoarthritis and rheumatoid arthritis. Reviews the inflammatory processes of both conditions and the stem cell approaches under study [9].

Case report of one. One paper describes a single patient with scalp psoriasis treated with conditioned medium from mesenchymal stem cells [1]. The reported severity score fell from 28 to 0 over one month [1]. One patient cannot show what happens in others [1].

Animal study. One paper tested a polyherbal Ayurvedic formulation, Dhanwantaram kashayam, in rats with diabetes [4]. It restored antioxidant enzyme activity and lowered lipid levels in those rats [4]. The paper describes the formulation as a preparation from plants [4]. The paper suggests it could be developed as a dietary supplement that might ease diabetes complications [4].

What the papers do and do not show

The nine papers are reviews, one case report of a single patient, and one animal study ([1] through [9]). None of them is a trial that tests a treatment in a group of people with a control group, and none is evidence that a treatment works for a condition named in its title ([1] through [9]). ClinicalTrials.gov lists one phase 2 study sponsored by the same institute, NCT06789302, which was not yet recruiting when checked, has an estimated enrollment of 120, and has no results posted [13].

How to check any author's publications

Search the founder's page, which lists the same papers, and compare them with the list above. Each paper's PubMed record is linked from that page. Registered trials for the same field are listed on ClinicalTrials.gov. The other guides cover stem cell research and the knee, peripheral neuropathy, systemic infusion and aging.

Regulatory Status

A 2026 review of FDA regulation of biologics examines how that oversight applies to stem cell products [12]. Our stem cell therapy is not approved by the FDA.

References

Every source named in this guide is listed here with its links where they exist: PubMed record, DOI, free full text, trial registration or agency page. Entries note the study type and, where the paper reports it, the number of people studied.

  1. 1.Seetharaman R, Mahmood A, Kshatriya P, et al. Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study. Case reports in dermatological medicine. 2019 2019(8309103).Case series, 1 patient.PubMed 31186972DOI 10.1155/2019/8309103Free full text PMC6521531
  2. 2.Seetharaman R, Mahmood A, Kshatriya P, et al. An Overview on Stem Cells in Tissue Regeneration. Current pharmaceutical design. 2019 25(2086-2098).Narrative review.PubMed 31298159DOI 10.2174/1381612825666190705211705
  3. 3.Mahmood A, Seetharaman R, Kshatriya P, et al. Stem Cell Transplant for Advanced Stage Liver Disorders: Current Scenario and Future Prospects. Current medicinal chemistry. 2020 27(6276-6293).Narrative review.PubMed 31584360DOI 10.2174/0929867326666191004161802
  4. 4.Renganathan S, Srivastava A, Pillai RG Dhanwantaram kashayam, an Ayurvedic polyherbal formulation, reduces oxidative radicals and reverts lipids profile towards normal in diabetic rats. Biochemistry and biophysics reports. 2020 22(100755).Preclinical study.PubMed 32368622DOI 10.1016/j.bbrep.2020.100755Free full text PMC7186759
  5. 5.Esquivel D, Mishra R, Srivastava A Stem Cell Therapy Offers a Possible Safe and Promising Alternative Approach for Treating Vitiligo: A Review. Current pharmaceutical design. 2020 26(4815-4821).Narrative review.PubMed 32744962DOI 10.2174/1381612826666200730221446
  6. 6.Mishra R, Dhawan P, Srivastava AS, et al. Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy. World journal of stem cells. 2020 12(1050-1066).Narrative review.PubMed 33178391DOI 10.4252/wjsc.v12.i10.1050Free full text PMC7596447
  7. 7.Esquivel D, Mishra R, Soni P, et al. Stem Cells Therapy as a Possible Therapeutic Option in Treating COVID-19 Patients. Stem cell reviews and reports. 2021 17(144-152).Narrative review.PubMed 32740890DOI 10.1007/s12015-020-10017-6Free full text PMC7395577
  8. 8.Esquivel D, Mishra R, Srivastava A Mesenchymal Stem Cell Therapy for Treating the Underlying Causes of Diabetes Mellitus and Its Consequences. Current stem cell research & therapy. 2024 19(662-668).Narrative review.PubMed 37055904DOI 10.2174/1574888X18666230411111320
  9. 9.Esquivel D, Mishra R, Srivastava A Potential use of stem cell therapies for treating osteoarthritis and rheumatoid arthritis. Annals of translational medicine. 2024 12(72).Narrative review.PubMed 39118961DOI 10.21037/atm-23-1951Free full text PMC11304433
  10. 10.Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006 8(315-7).Consensus statement.PubMed 16923606DOI 10.1080/14653240600855905
  11. 11.Caplan AI Mesenchymal Stem Cells: Time to Change the Name!. Stem cells translational medicine. 2017 6(1445-1451).Narrative review.PubMed 28452204DOI 10.1002/sctm.17-0051Free full text PMC5689741
  12. 12.Segal J US Food and Drug Administration and Regulation Issues for Biologics: The Sands Are Shifting. Facial plastic surgery clinics of North America. 2026 34(501-507).Narrative review.PubMed 42392663DOI 10.1016/j.fsc.2026.05.006
  13. 13.A Double-Blind, Randomized, Placebo-Controlled Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of DT2-SCT in Subjects With Type 2 Diabetes Mellitus. 2025.Registered trial, 120 estimated.ClinicalTrials.gov NCT06789302

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